Landmark Publication on Vitamin C for COVID-19

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No matter what the mainstream media need you to suppose, many are beginning to notice the reality, which is that each vitamin C (ascorbic acid) and vitamin D have an infinite quantity of analysis displaying they supply vital immune operate enhancements, and that your immune operate is your frontline protection in opposition to all sickness, together with COVID-19.

As reported within the paper “Optimum Dietary Standing for a Nicely-Functioning Immune System Is an Necessary Issue to Defend In opposition to Viral Infections,” revealed April 23, 2020:1

“The function vitamin performs in supporting the immune system is well-established. A wealth of mechanistic and scientific knowledge present that nutritional vitamins, together with nutritional vitamins A, B6, B12, C, D, E, and folate; hint components, together with zinc, iron, selenium, magnesium, and copper; and the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid play vital and complementary roles in supporting the immune system.

Insufficient consumption and standing of those vitamins are widespread, resulting in a lower in resistance to infections and as a consequence a rise in illness burden.”

Excessive-Dose Vitamin C Acts as an Antiviral Drug

As defined within the video above by Dr. Andrew Saul, editor-in-chief of the Orthomolecular Medication Information Service, at extraordinarily excessive doses, vitamin C really acts as an antiviral drug, successfully inactivating viruses.

His Tokyo presentation, “Orthomolecular Medication and Coronavirus Illness: Historic Foundation for Dietary Therapy,” highlights the truth that when used as a therapy, excessive doses of vitamin C — usually 1,000 instances greater than the U.S. Really helpful Dietary Allowance (RDA) — are wanted.

It is a cornerstone of medical science that dose impacts therapy end result, however this premise is not accepted with regards to vitamin remedy the way in which it’s with drug remedy. Most vitamin C analysis has used insufficient, low doses, which do not result in scientific outcomes.

“The medical literature has ignored over 80 years of laboratory and scientific research on high-dose ascorbate remedy,” Saul notes, including that whereas it is extensively accepted that vitamin C is helpful in combating sickness, controversy exists over to what extent. “Reasonable portions present efficient prevention,” he says, whereas “massive portions are therapeutic.”

Landmark Paper Places Vitamin C on the COVID-19 Therapy Map

Whereas well being authorities and mainstream media have ignored, if not outright opposed, using vitamin C and different dietary supplements within the therapy of COVID-19, citing lack of scientific proof, we now have a landmark overview2 recommending using vitamin C as an adjunctive remedy for respiratory infections, sepsis and COVID-19.

The overview,3 revealed December 7, 2020, within the journal Vitamins, was co-written by Dr. Paul Marik who, in 2017, developed a groundbreaking vitamin C-based treatment for sepsis. Marik is now heading up the Entrance Line COVID-19 Vital Care Alliance,4 which has developed a extremely profitable therapy for COVID-19.

The COVID-19 protocol was initially dubbed MATH+ (an acronym based mostly on the important thing parts of the therapy), however after a number of tweaks and updates, the prophylaxis and early outpatient therapy protocol is now often called I-MASK+5 whereas the hospital therapy has been renamed I-MATH+,6 because of the addition of the drug Ivermectin. Vitamin C stays a central element of this therapy, although.

(The 2 protocols7,8 can be found for obtain on the FLCCC Alliance web site in a number of languages. The scientific and scientific rationale for the I-MATH+ hospital protocol has additionally been peer-reviewed and was revealed within the Journal of Intensive Care Medication9 in mid-December 2020.) As defined within the Vitamins overview summary:10

“There are restricted confirmed therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating results make it a possible therapeutic candidate, each for the prevention and amelioration of COVID-19 an infection, and as an adjunctive remedy within the crucial care of COVID-19.

This literature overview focuses on vitamin C deficiency in respiratory infections, together with COVID-19, and the mechanisms of motion in infectious illness, together with help of the stress response, its function in stopping and treating colds and pneumonia, and its function in treating sepsis and COVID-19.

The proof up to now signifies that oral vitamin C (2-8 g/day) might cut back the incidence and length of respiratory infections and intravenous vitamin C (6-24 g/day) has been proven to cut back mortality, intensive care unit (ICU) and hospital stays, and time on mechanical air flow for extreme respiratory infections …

Given the favorable security profile and low value of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it might be worthwhile testing sufferers’ vitamin C standing and treating them accordingly with intravenous administration inside ICUs and oral administration in hospitalized individuals with COVID-19.”

Worldwide Vitamin C Marketing campaign Launched

In a December 16, 2020, motion alert,11 Rob Verkerk, Ph.D., founder and scientific director of the Alliance for Pure Well being, introduced the launch of a global vitamin C marketing campaign12 in response to the landmark overview, which “places all of the arguments and science in a single, neat place.”

As famous by Verkerk, there are a number of causes to take supplemental vitamin C. First, your physique can not make it. Second, most individuals don’t get ample quantities from their eating regimen and, third, your physique’s requirement for vitamin C can enhance 10-fold at any time when your immune system is challenged by an an infection, illness or bodily trauma.

Actually, the Vitamins overview13 factors out that it is common for hospitalized sufferers to have overt vitamin C deficiency, outlined as a blood degree at or beneath 11 µmol/L. That is notably true for older sufferers and people hospitalized for respiratory infections.

In accordance with the authors, “Vitamin C concentrations are three to 10 instances greater within the adrenal glands than in some other organ. It’s launched from the adrenal cortex beneath circumstances of physiological stress (ACTH stimulation), together with viral publicity, elevating plasma ranges fivefold.” In his motion alert, Verkerk notes:14

“Taking vitamin C as a preventative after which, upping your consumption if you happen to’re contaminated, is a no brainer. So is utilizing vitamin C intravenously for these with acute respiratory infections, or sepsis, in crucial care.

A lot so, that we argue — given the now obtainable proof — that docs and different well being professionals who keep away from suggestions on vitamin C in relation to COVID illness prevention and therapy, must be thought-about medically negligent …

There may be ample proof to point out that dietary supplements like zinc, vitamin C, and vitamin D will help stop and deal with COVID-19, however we’re prevented from studying about these advantages by the federal authorities.

As a result of dietary supplements should not, and may by no means turn into, FDA-approved, they can’t declare to have an effect on illness, even after we know they’ll. This nonsense has to cease.”

How Vitamin C Works

As talked about, the Vitamins overview15 particulars vitamin C’s mechanisms of motion and the way it helps in circumstances of infectious illness, together with the widespread chilly, pneumonia, sepsis and COVID-19. For starters, vitamin C has the next primary properties:

  • Anti-inflammatory
  • Immunomodulatory
  • Antioxidant
  • Antithrombotic
  • Antiviral

Useful antiviral results apply to each the innate and adaptive immune programs. When you’ve got an an infection, vitamin C improves your immune operate partially by selling the event and maturation of T-lymphocytes, a kind of white blood cell that’s a necessary a part of your immune system.

Phagocytes, immune cells that kill pathogenic microbes, are additionally ready to absorb oxidized vitamin C and regenerate it to ascorbic acid. With regard to COVID-19 particularly, vitamin C:16

Helps downregulate inflammatory cytokines, thereby decreasing the chance of a cytokine storm. It additionally reduces irritation by means of the activation of NF-κB and by rising superoxide dismutase, catalase and glutathione. Epigenetically, vitamin C regulates genes concerned within the upregulation of antioxidant proteins and downregulation of proinflammatory cytokines

Protects your endothelium from oxidant harm

Helps restore broken tissues

Upregulates expression of Kind-1 interferons, your major antiviral protection mechanism, which SARS-CoV-2 downregulates

Eliminates ACE2 upregulation induced by IL-7. That is notably noteworthy, because the ACE2 receptor is the entry level for SARS-CoV-2 (the virus’ spike protein binds to ACE2)

Seems to be a strong inhibitor of Mpro, a key protease (enzyme) in SARS-CoV-2 that prompts viral nonstructural proteins

Regulates neutrophil extracellular lure formation (NETosis), a maladaptive response that leads to tissue harm and organ failure

Enhances lung epithelial barrier operate in an animal mannequin of sepsis by selling epigenetic and transcriptional expression of protein-channels on the alveolar capillary membrane that regulate alveolar fluid clearance

Mediates the adrenocortical stress response, notably in sepsis

The graph beneath, from the Vitamins overview, illustrates the important thing methods by which vitamin C ameliorates the pathology seen in COVID-19.


Nebulized Peroxide Might Be Even Higher

The attractive graphic above makes it actually clear that one of many major ways in which vitamin C works is thru the technology of reactive oxygen species. Guess what the first one is? Should you guessed hydrogen peroxide give your self a excessive 5!

It’s extremely seemingly that the peroxide kinds a really highly effective signaling operate that stimulates the immune system to defeat no matter viral risk it’s uncovered to. This is among the the reason why nebulized peroxide is my absolute favourite intervention for acute viral diseases. It’s extremely efficient, cheap and has no negative effects when used on the very low doses really helpful (0.1%, which is 30 instances much less concentrated than common drugstore 3% peroxide).

My video beneath discusses the main points of how you need to use this remedy. The secret is to have your nebulizer already bought and able to go in order that it’s locked and loaded and you do not have to exit and buy something if you happen to or a beloved one will get sick. You’ll be able to nonetheless use vitamin C with the peroxide, as they seemingly have a strong synergy and use totally different complimentary mechanisms.

Since you aren’t utilizing full power 3% peroxide and diluting it by 30 to 50 instances, it’s unlikely the stabilizers will current an issue, however to be protected, it’s best to make use of FOOD-GRADE peroxide. Additionally, don’t dilute it with plain water as the shortage of electrolytes within the water can harm your lungs if you happen to nebulize it. As a substitute, use saline or add a small quantity of salt to the water to eradicate this threat.

peroxide dilution charts

Medical Proof

The Vitamins overview17 additionally consists of scientific proof for the function of vitamin C in COVID-19, noting that early oral supplementation may assist stop a light case from creating into one thing extra severe. In sufferers with crucial signs, intravenous administration of vitamin C has been proven to hurry up restoration, decreasing each ICU stays and mortality.

Apparently, vitamin C deficiency and COVID-19 share lots of the similar threat elements, together with male gender, darker pores and skin, older age and comorbidities akin to diabetes, hypertension and COPD. All of those subgroups are at elevated threat for extreme COVID-19 and, in line with the authors, all “have additionally been proven to have decrease serum vitamin C ranges.”

Commenting on the scientific proof supporting using vitamin C within the therapy of COVID-19, the authors write:18

“There are at the moment 45 trials registered on Clinicaltrials.gov investigating vitamin C with or with out different therapies for COVID-19. Within the first RCT to check the worth of vitamin C in critically unwell COVID-19 sufferers, 54 ventilated sufferers in Wuhan, China, had been handled with a placebo (sterile water) or intravenous vitamin C at a dose of 24 g/day for 7 days …

The extra severely unwell sufferers with SOFA [sequential organ failure assessment] scores ≥ 3 within the vitamin C group exhibited a discount in 28-day mortality: 18% versus 50% in univariate survival evaluation (Determine 2). No study-related hostile occasions had been reported.”

Determine 2 beneath, from model 1 of the research,19 “Excessive-Dose Vitamin C Infusion for the Therapy of Critically Sick COVID-19,” posted on the preprint server Analysis Sq. August 10, 2020 (up to date September 23, at which level it was renamed20), exhibits the 28-day mortality charges between critically unwell COVID-19 sufferers given high-dose IV vitamin C (HDIVC) in comparison with these given a placebo.

28 day mortality rates

The Nutrient overview additionally summarizes findings from different COVID-19 trials utilizing vitamin C, in addition to a number of case reviews:21

“Within the UK, the Chelsea and Westminster hospital ICU, the place grownup ICU sufferers had been administered 1 g of intravenous vitamin C each 12 h along with anticoagulants, has reported 29% mortality, in comparison with the common 41% reported by the Intensive Care Nationwide Audit and Analysis Centre (ICNARC) for all UK ICUs …

The Frontline COVID-19 Vital Care Professional Group (FLCCC), a bunch of emergency drugs consultants, have reported that, with the mixed use of 6 g/day intravenous vitamin C (1.5 g each 6 h), plus steroids and anticoagulants, mortality was 5% in two ICUs within the US (United Memorial Hospital in Houston, Texas, and Norfolk Common Hospital in Norfolk, Virginia), the bottom mortality charges of their respective counties.

A case report of 17 COVID-19 sufferers who got 1 g of intravenous vitamin C each 8 h for 3 days reported a mortality charge of 12% with 18% charges of intubation and mechanical air flow and a big lower in inflammatory markers, together with ferritin and D-dimer, and a development in the direction of reducing FiO2 necessities.

One other case of sudden restoration following high-dose intravenous vitamin C has additionally been reported. Whereas these case reviews are topic to confounding and should not prima facie proof of results, they do illustrate the feasibility of utilizing vitamin C for COVID-19 with no hostile results reported.”

How A lot Vitamin C Do You Want?

As detailed within the introduction of the Vitamins overview,22 primates and people are depending on an ample provide of vitamin C from fruit and veggies. Gorillas want 4.5 grams a day, whereas smaller primates weighing round 7.5 kilos want about 600 mg per day. This provides us a clue as to what the human requirement is likely to be, and it is fairly a bit greater than the day by day really helpful consumption. In accordance with the authors:23

“The EU Common Requirement of 90 mg/day for males and 80 mg/day for girls is to keep up a traditional plasma degree of fifty µmol/L, which is the imply plasma degree in UK adults. That is ample to forestall scurvy however could also be insufficient when an individual is beneath viral publicity and physiological stress.

An skilled panel in cooperation with the Swiss Society of Vitamin really helpful that everybody complement with 200 mg ‘to fill the nutrient hole for the final inhabitants and particularly for the adults age 65 and older. This complement is focused to strengthen the immune system.’ The Linus Pauling Institute recommends 400 mg for older adults (>50 years outdated).

Pharmacokinetic research in wholesome volunteers help a 200-mg day by day dose to provide a plasma degree of circa 70 to 90 µmol/L. Full plasma saturation happens between 1 g day by day and three g each 4 hours, being the very best tolerated oral dose, giving a predicted peak plasma focus of circa 220 µmol/L.

The identical dose given intravenously raises plasma vitamin C ranges roughly tenfold. Greater intakes of vitamin C are prone to be wanted throughout viral infections with 2–3 g/day required to keep up regular plasma ranges between 60 and 80 µmol/L. Whether or not greater plasma ranges have extra profit is but to be decided, however could be in line with the outcomes of the scientific trials mentioned on this overview.”

Whereas high-dose vitamin C regimens sometimes name for intravenous administration, if treating a viral an infection at house (be it COVID-19 or one thing else), you possibly can use oral liposomal vitamin C, as this lets you take far greater doses with out inflicting free stools.

You’ll be able to take as much as 100 grams of liposomal vitamin C with out issues and get actually excessive blood ranges, equal to or greater than intravenous vitamin C. I view that as an acute therapy, nonetheless. I discourage folks from taking mega doses of vitamin C regularly if they don’t seem to be really sick, as a result of it’s basically a drug — or no less than it really works like one.

Saul, who has labored with and really helpful vitamin C for many of his skilled life suggests taking “sufficient vitamin C to be symptom-free,” no matter dosage that is likely to be. Once you’re properly, you sometimes do not want greater than the 200 mg to 400 mg really helpful within the quote above.